Accession Number : ADA302429

Title :   Vaccines to Breast Cancer Based on P53 Mutants.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST

Personal Author(s) : Ertl, Hildegund C.

PDF Url : ADA302429

Report Date : SEP 1995

Pagination or Media Count : 9

Abstract : The most commonly found molecular abnormality in human malignancies, (including mammary adenocarcinoma,) are well-defined point mutations of p53 that cluster in mutational hotspots and affect the ability of the protein to bind to DNA. Single amino acid exchanges of a self protein can break tolerance and result in activation of a specific T-cell response. In our application we proposed to test the ability of various p53 mutations using a variety of different vaccine constructs. In the first year of our application we concentrated on generating several different vaccine expressing p53 mutations. In addition, we explored different avenues in order to establish a tumor model for defined p53 mutations.

Descriptors :   *MUTATIONS, *T LYMPHOCYTES, *VACCINES, *MAMMARY GLANDS, *BREAST CANCER, ACTIVATION, MODELS, HUMANS, MOLECULES, PROTEINS, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, RESPONSE, TOLERANCE, HOT SPOTS, AMINO ACIDS, ABNORMALITIES, CANCER.

Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE