Accession Number : ADA302433

Title :   Prevalence of Prognostic Biomarkers in Archival Specimens and Breast Cancer Survival Among White, Black, and Asian Women.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : KAISER FOUNDATION RESEARCH INST OAKLAND CA

Personal Author(s) : Krieger, Nancy

PDF Url : ADA302433

Report Date : SEP 1995

Pagination or Media Count : 35

Abstract : This study addresses two questions: (1) how does prevalence of prognostic biomarkers in old, archival paraffin-embedded tumor biopsy specimens obtained from 50 Asian, 50 black, and 50 white women diagnosed with breast cancer in Oakland, CCA between 1966 and 1990 compare across racial/ethnic groups and to that observed among recent paraffin-embedded specimens, and (2) what is the relationship of these biomarkers to survival, controlling for other biological and socio economic risk factors that affect survival? In Year 1, we have, as planned: (a) abstracted medical chart data on tumor characteristics and treatment for all 150 women, (b) appended these data to an existing database with the women? 5 sociodemographic and reproductive characteristics, (c) determined their vital status as of December 31, 1994, (d) located tumor blocks for 135 of these women, and (e) measured, by immunohistochemistry/image analysis, the following prognostic biomarkers: estrogen, progesterone, androgen, and epidermal growth factor receptors, cathepsin-D, her-2/neu, Ps2, p53, Ki67, and DNA ploidy. Tasks for Year 2 include: (a) appending the assay and vital status data to the study's data base, (b) comparing biomarker distribution among the cases and more recent biopsy specimens, and (c) describing and comparing biomarker distributions and prognostic values by race/ ethincity and social class.

Descriptors :   *RACE(ANTHROPOLOGY), *MAMMARY GLANDS, *BIOPSY, *PROGESTERONE, *BREAST CANCER, DATA BASES, SURVIVAL(GENERAL), DEOXYRIBONUCLEIC ACIDS, CHEMISTRY, IMAGES, ETHNIC GROUPS, MARKERS, VALUE, IMMUNOLOGY, ARCHIVES, WOMEN, ASIA, CANCER, HISTOLOGY, TRACER STUDIES, ESTROGENS.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE