Accession Number : ADA302659

Title :   Ret Receptor: Functional Consequences of Oncogenic Rearrangements.

Descriptive Note : Annual rept. 15 Sep 94-14 Sep 95,

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Taylor, Susan S.

PDF Url : ADA302659

Report Date : OCT 1995

Pagination or Media Count : 27

Abstract : The overall goals of this proposal are to characterize the gene product of a novel oncogene ret/ptc2. This protein is a fusion of the RIalpha subunit of cAMP-dependent protein kinase and the kinase domain of a receptor tyrosine kinase. The ligand for the RET receptor is still unknown, however, this gene is associated with many inherited dominant cancers such as MEN2A, MEN2B, and Hirschprung's disease. Ret/ptc2 is a constitutively active form of the RET receptor, and we believe it will be a prototype for other oncogene receptor tyrosine kinases. Our goals are to express large amounts of ret/ptc2 to establish the structural basis for its activation, to establish how the RET receptor functions in vivo by identifying the proteins it interacts with, and to model the ret kinase domain and map the sites of mutation that are known to be associated with various diseases. We are also constructing chimeras that resemble ret/ptc2 using the kinase domains of the EGF receptor and the insulin receptor.

Descriptors :   *PROTEINS, *DISEASES, *ONCOGENIC VIRUSES, *BREAST CANCER, FUNCTIONS, ACTIVATION, SITES, MUTATIONS, GENES, IN VIVO ANALYSIS, SENSE ORGANS, CANCER, INSULIN.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE