Accession Number : ADA302737

Title :   KTP Laser-Induced Biomodulation of the Wound-Healing Process.

Descriptive Note : Rept. for 1 Feb 87-31 Jan 91,

Corporate Author : VANDERBILT UNIV NASHVILLE TN

Personal Author(s) : Kyzer, Michael D. ; Aly, Al S. ; Ossoff, Robert H.

PDF Url : ADA302737

Report Date : 1991

Pagination or Media Count : 30

Abstract : The KTP laser (wavelength, 532 nm) was used in a subablative format to determine whether low energy density irradiation would affect the normal healing by primary intention of scalpel skin incisions in rats. Two longitudinal lased strips were created by a 1 cm diameter defocused beam on the shaved, cleaned dorsal epidermis of 32 Sprague-Dawley rats; one strip was produced with a 2.0 W beam (54 J, or 18 J/cm2 total dose), and the other with a 3.5 W beam (94.5 J, or 31.5 J/cm2, total dose). Scalpel incisions were made longitudinally within the irradiated zones, using contralateral scalpel incisions on unirradiated skin as controls. Tensiometric analysis of wound strength was performed at 3, 7, 14, and 23 days following surgery. The data from fresh tissue tensiometry indicate that KTP laser irradiation of skin incisions results in a triphasic tensile strength response for the 54 J (2.0 W) exposure, but not for the 94.5 J (3.5 W) exposure. For the 54 J irradiated incisions, the fresh tensile strength is greater than control at days 3 and 23, but less than control at the intermediate days 7 and 14. The 94.5 J irradiated incisions are consistently weaker than controls. These effects may be explained by the interplay of localized transient cellular injury effected by the low energy density laser and a concomitant biomodulatory response.

Descriptors :   *TISSUES(BIOLOGY), *LASERS, *LASER BEAMS, *WOUNDS AND INJURIES, *LOW DENSITY, *HEALING, *LASER MEDICAL DIAGNOSIS, TRANSIENTS, TENSILE STRENGTH, RATS, FREE ELECTRON LASERS, LOW ENERGY, STRENGTH(GENERAL), IRRADIATION, CARBON DIOXIDE, SURGERY, CELLS(BIOLOGY), NECROSIS, EPIDERMIS.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Medical Facilities, Equipment and Supplies
      Lasers and Masers

Distribution Statement : APPROVED FOR PUBLIC RELEASE