Accession Number : ADA302818

Title :   Breast Tissue Dosimetry of PhIP(2-amino-1-methyl-6-phenylimidazo 4, 5B pryidine) at Human-Relevant Exposures.

Descriptive Note : Annual rept. 15 Jul 94-30 Sep 95,

Corporate Author : CALIFORNIA UNIV LIVERMORE RADIATION LAB

Personal Author(s) : Turteltaub, Kenneth W.

PDF Url : ADA302818

Report Date : OCT 1995

Pagination or Media Count : 20

Abstract : A great deal of concern has been expressed recently that cooking meat produces genotoxic substances which may contribute to the incidence of human cancers. One important component of these substances is PhIP which has been shown to cause breast tumors in rats. Given the recent findings that mutations in the P53 gene of breast cancer patients are more similar to mutations caused by chemical mutagens than to spontaneous mutations, the role of compounds like PhIP in the etiology of human breast cancer should be critically evaluated. This work is focused on establishing the dosimetry of PhIP in females rodents relative to male rodents at human-relevant exposures. It is also focused on assessing the dose effects of metabolism. Finally it is focused on development of sensitive methods for the measurement of DNA adducts and metabolites in breast tissue that can be later applied to humans to assess susceptibility.

Descriptors :   *DEOXYRIBONUCLEIC ACIDS, *MUTATIONS, *MUTAGENS, *MAMMARY GLANDS, *DOSIMETRY, *BREAST CANCER, MEASUREMENT, TISSUES(BIOLOGY), METHYLAMINE, RATS, HUMANS, CHEMICALS, NEOPLASMS, SENSITIVITY, METABOLISM, ETIOLOGY, DOSAGE, MALES, PATIENTS, RODENTS, AMINO ACIDS, FEMALES, METABOLITES, PHENYLAMINES.

Subject Categories : Medicine and Medical Research
      Biochemistry
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE