Accession Number : ADA303127

Title :   Support for HIV-1 Intervention Therapy.

Descriptive Note : Annual rept. 30 Sep 94-29 Sep 95,

Corporate Author : SRA TECHNOLOGIES INC ROCKVILLE MD

Personal Author(s) : Weislow, Owen S.

PDF Url : ADA303127

Report Date : OCT 1995

Pagination or Media Count : 72

Abstract : Since 1992 SRA Technologies, Inc. has provided services in support of DoD interventional trials for HIV. Three working groups were established in the areas of molecular biology, cellular phenotyping and drug testing. Production level services were provided for virus isolation, expansion, titration, sequencing, mutational analysis and drug susceptibility testing. Significant progress was made in the development of new assays for drug resistance, antibody neutralization, mutational analysis and for efficacy analysis of suggested by the discovery df factors from CD3/CD28 antibody stimulated cells that inhibit HIV Infection in Vitro.

Descriptors :   *INFECTIOUS DISEASES, *VIRUSES, *HUMAN IMMUNODEFICIENCY VIRUSES, *ACQUIRED IMMUNE DEFICIENCY SYNDROME, *RESISTANCE(BIOLOGY), TEST AND EVALUATION, PRODUCTION, NEUTRALIZATION, ISOLATION, MUTATIONS, IN VITRO ANALYSIS, ANTIBODIES, MOLECULAR BIOLOGY, GENES, DRUGS, ANTIVIRAL AGENTS, ASSAYING.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE