Accession Number : ADA303181

Title :   Biological Specimen Bank to Enhance Population Based Studies of Inherited Breast Cancer Genes.

Descriptive Note : Annual rept. 30 Sep 94-29 Sep 95,

Corporate Author : DANA-FARBER CANCER INST BOSTON MA

Personal Author(s) : Li, Frederick P.

PDF Url : ADA303181

Report Date : OCT 1995

Pagination or Media Count : 144

Abstract : The technical objectives of this infrastructure enhancement project are to establish a population- based biological specimen and data bank on 225 women with invasive breast cancer, aged 35 and under. This new resource will be available to multiple investigators to identify and determine the frequency of inherited gene alterations in p53, BRCAl and additional inherited breast cancer susceptibility genes, and studies of gene-environmental interactions. Our cases will help provide the first estimates of germinal mutation frequency among the 90 percent of young patients who have no family history of breast cancer. Work is on schedule so that 225 young cases will be ascertained over 24 months through the tumor incidence registries in Connecticut, Massachusetts and 7 regions in California. Demographic, epidemiologic and family history data will be collected, paraffin-fixed tumor tissue retrieved, and a fresh blood specimen will be processed to produce genomic DNA, a plasma specimen, and viably frozen cells. A computerized file of the epidemiologic data and specimen data will be made accessible to all researchers via the Internet.

Descriptors :   *HISTORY, *GENES, *WOMEN, *MAMMARY GLANDS, *GERM CELLS, *BREAST CANCER, DATA BASES, FREQUENCY, CELLS, NEOPLASMS, POPULATION, DEOXYRIBONUCLEIC ACIDS, MUTATIONS, FREEZING, RESOURCES, CALIFORNIA, CONNECTICUT, EPIDEMIOLOGY, CANCER, MASSACHUSETTS.

Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE