Accession Number : ADA303250

Title :   Breast Tumor Immunity in the Paraneoplastic Neurologic Disorders.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : Darnell, Robert B.

PDF Url : ADA303250

Report Date : OCT 1995

Pagination or Media Count : 14

Abstract : Paraneoplastic neurologic disease (PND) antigens are proteins normally expressed specifically in neurons that are expressed ectopically in tumors. It is believed that when expressed in tumors outside of the immunologically privilege nervous system, PND antigens stimulate the development of anti-tumor immunity, but also stimulate an autoimmune neuronal degeneration. We are studying PND's associated with breast cancer and immunity to the Nova and cdr2 antigens, assaying PND expression in clinical breast tumor specimens, and establishing animal models for the disorders. A prerequisite to studying the abnormal expression of PND antigens is an understanding of their normal expression. We have found that the Ndva gene and antigen is normally restricted in expression to neurons. Strikingly, we have discovered that the cdr2 gen is widely expressed, but that its mRNA is under tight translational control, so that the cdr2 antigen is normally made only in neurons and (immune privileged) testes. This observation provides a novel insight to the biology:df breast tumors, suggesting that they may dysregulate translational control to express abnormal proteins, and alters our approach to the analysis of cdr2 expression in vivo. We have also made significant progress in generating gene constructs to generate mouse models of PND.

Descriptors :   *NERVOUS SYSTEM DISEASES, *NERVE CELLS, *MEDICAL SERVICES, *ANTIGENS, *ABNORMALITIES, *MAMMARY GLANDS, *BREAST CANCER, BIOLOGY, MODELS, PROTEINS, CLINICAL MEDICINE, DISEASES, NEOPLASMS, NERVOUS SYSTEM, GENES, ANIMALS, MICE, IMMUNITY, ASSAYING, AUTOIMMUNIZATION, CANCER, BIODETERIORATION, TESTES.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE