Accession Number : ADA303452

Title :   Anti-Emetic Drug Effects on Performance Phase 1: Laboratory Study.

Descriptive Note : Interim rept. Sep 93-Sep 95,

Corporate Author : SYSTEMS RESEARCH LABS INC DAYTON OH

Personal Author(s) : Benline, Terry A. ; French, Jonathan ; Wing, John

PDF Url : ADA303452

Report Date : DEC 1995

Pagination or Media Count : 89

Abstract : The objectives of this study were to evaluate the effects of two anti-emetic drugs, granisetron ( 2 mg p.o.) and ondansetron ( 8 mg p.o.) on basic cognitive skills and complex task performance. The experimental approach, involving 24 active-duty, military subjects was a placebo controlled, double blind, crossover design with a positive control (prochlorperazine 10 mg p.o.) condition. Testing was accomplished during the evening and early morning hours, between 1630 h and 0230 h. Therefore, fatigue stemming from an extended work period and a disrupted work/rest cycle, was also part of the study design. Data were collected on: cognitive and psychomotor effects, affective state changes, temperature, serum-drug levels and side effects. The drugs of interest, granisetron and ondansetron, were extremely well tolerated and with no obvious side effects when compared to the placebo condition. Two of five cognitive tests detected a positive control effect and nearly all or the measurement instruments demonstrated a fatigue effect There was no evidence of any cognitive, psychomotor or subjective state changes caused by either granisetron or ondansetron.

Descriptors :   *DRUGS, *ANTIEMETICS, *EMETICS, TEST AND EVALUATION, CONTROL, MILITARY PERSONNEL, EXPERIMENTAL DATA, JOBS, MILITARY ASSISTANCE, PERFORMANCE(HUMAN), COGNITION, FATIGUE, LABORATORIES, BLOOD SERUM, PLACEBOS, PSYCHOMOTOR TESTS, APPROACH.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE