Accession Number : ADA303471

Title :   Rapid 4D MRI of Gad-DTPA Enhancement for Breast Lesion Characterization.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Chenevert, Thomas L.

PDF Url : ADA303471

Report Date : OCT 1995

Pagination or Media Count : 17

Abstract : The objectives of this project are refinement and clinical application of new methods designed to defeat the tradeoff between spatial resolution, temporal resolution and acquisition volume in dynamic gadolinium-enhanced MR mammography. The approach, referred to as '3D keyhole' involves specialized software for data acquisition and reconstruction that allow dynamic scans of 32 sections through both breasts to be acquired at l3second temporal resolution. This methodology provides greater precision in numerical fitting of temporal enhancement features of lesions. Extensive data processing tools have been developed to visualize dynamic contrast changes and reduce lesion temporal enhancement curves to fitted time and amplitude constants. This methodology is being applied in a prospective 4 year study of 100 women in whom a breast abnormality, detected by conventional means, is to be characterized by surgical biopsy. The targeted patient accrual in of 25 patients per year has been achieved. The hypothesized trend for malignancies to display rapid/strong contrast enhancement due to angiogenesis is apparent, although, some false positives and negatives do persist.

Descriptors :   *NUMERICAL ANALYSIS, *CLINICAL MEDICINE, *TRADE OFF ANALYSIS, *MAMMARY GLANDS, *BREAST CANCER, SCANNING, COMPUTER PROGRAMS, DATA PROCESSING, SPATIAL DISTRIBUTION, VOLUME, CONTRAST, OPTIMIZATION, ACQUISITION, TOOLS, DYNAMICS, RESOLUTION, PROCESSING EQUIPMENT, DISPLAY SYSTEMS, CONSTANTS, DATA ACQUISITION, AMPLITUDE, ABNORMALITIES, LESIONS, FITTINGS, MAMMOGRAPHY.

Subject Categories : Medicine and Medical Research
      Economics and Cost Analysis
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE