Accession Number : ADA303667

Title :   Biological Markers of Environmental Carcinogens in Breast Cancer.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : COLUMBIA UNIV NEW YORK

Personal Author(s) : Perera, Frederica

PDF Url : ADA303667

Report Date : OCT 1995

Pagination or Media Count : 16

Abstract : Breast cancer afflicts one in nine women by the age of 85 and is the second leading cause of cancer death among American women. There is growing concern that environmental contaminants such as the polycyclic aromatic hydrocarbons (PNIs), heterocyclic amines (HA), cigarette smoke constituents and organochlorine residues are contributor to breast cancer development. To avoid some of the limitations of interview-based epidemiology, biomarkers of exposure (carcinogen-ENA adducts) and early effect (p53 mutations) have been incorporated into a hospital-based case-control study to facilitate evaluation of whether these exposures play a role in human breast cancer development. During year one, an efficient system for identifying and enrolling cases, benign breast disease and healthy controls from private practices and clinics was established. To date 184 subjects have been enrolled. Blood samples from enrollees have been fractionated, aliquotted and stored in preparation for laboratory analysis. Questionnaire, pathology report and medical data abstraction and databasing are ongoing. The preliminary analysis of the questionnaire data has revealed that Dominican women are likely to have been heavily exposed to DDE.

Descriptors :   *CARCINOGENS, *CONTAMINATION, *ENVIRONMENTAL PROTECTION, *DEATH, *MAMMARY GLANDS, *BREAST CANCER, LABORATORY TESTS, ENVIRONMENTS, BIOLOGY, HUMANS, CLINICAL MEDICINE, DISEASES, EFFICIENCY, MEDICINE, AMINES, AROMATIC HYDROCARBONS, MARKERS, PATHOLOGY, WOMEN, QUESTIONNAIRES, HETEROCYCLIC COMPOUNDS, POLYCYCLIC COMPOUNDS, TOBACCO SMOKING.

Subject Categories : Medicine and Medical Research
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE