Accession Number : ADA303733

Title :   In Vivo Microscope MR Imaging of Breast Lesions.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s) : Zerhouni, Elias A.

PDF Url : ADA303733

Report Date : OCT 1995

Pagination or Media Count : 13

Abstract : An MR microscopy device was built for in vivo imaging of breast lesions as specified in our proposal. Small size RF reciever coils with diameters ranging from 3.2-7 cm were built and tested on phantoms. A frame to support the imaging coils was built that enables imaging in the prone and left or right decubitus positions. This frame was then tested on healthy volunteers and intitial clinical trials were begun. Three patients with suspicious lesions have been studied to date, with pathologic confirmation. To investigate the SNR performance, saline solution was imaged with various coil separations and diameters. The breast was compressed at the level of the suspected lesion between a pair of the surface coils positioned as close as possible to the lesion. The coils were connected to the scanner with the phased array method. Using the 3.2cm coils, the signal to noise ratio reached a level that enabled imaging with a resolution of 100pm and 3mm slice thickness.

Descriptors :   *COILS, *MICROSCOPES, *IN VIVO ANALYSIS, *LESIONS, *MAMMARY GLANDS, *SALINE SOLUTION, *BREAST CANCER, *MAGNETIC RESONANCE IMAGING, COMPRESSION, THICKNESS, SIGNAL TO NOISE RATIO, MICROSCOPY, SURFACES, IMAGES, SEPARATION, FRAMES, PATIENTS, PHASED ARRAYS, PHARMACOLOGY.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Nuclear Physics & Elementary Particle Physics

Distribution Statement : APPROVED FOR PUBLIC RELEASE