Accession Number : ADA303738

Title :   Hormones and Breast Cancer.

Descriptive Note : Annual rept. 30 Sep 94-29 Sep 95,

Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES SCHOOL OF MEDICINE

Personal Author(s) : Ursin, Giske

PDF Url : ADA303738

Report Date : OCT 1995

Pagination or Media Count : 19

Abstract : Grant consists of separate projects; The first aims at assessing the association between lifestyle factors (hormone use) and breast cancer; the second aims at elucidating the role of estrogen metabolism in the development of breast cancer; the third aims at understanding the relation of female hormone levels to changes in mammographic densities, a possible intermediate endpoint in cancer prevention studies. The first project uses data from a case-control study of Asian-American immigrants where the relative risks associated with oral contraceptive use will be assessed. The second project consists of two studies; a case-control study of postmenopausal breast cancer patients and a case-control study of premenopausal women with 'high' and 'normal' risk of breast cancer. Urinary estrogen metabolites will be compared to test the hypothesis that the 16-alpha pathway of estrone metabolism is associated with breast cancer risk. Project 3 is 2 studies of hormone induced changes in mammographic densities. These studies will test the hypothesis that reducing serum estrogen and progesterone levels reduces mammographic densities.

Descriptors :   *HORMONES, *METABOLISM, *MAMMARY GLANDS, CONTROL, HIGH RATE, RISK, HYPOTHESES, PATIENTS, WOMEN, PREVENTION, FEMALES, METABOLITES, URINE, PREVENTIVE MEDICINE, CANCER, PROGESTERONE, ESTROGENS.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE