Accession Number : ADA303835

Title :   Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 2. Results of Mouse Bone Marrow Micronucleus Test.

Descriptive Note : Final rept. Jul-11 Dec 92,

Corporate Author : TOXIKON CORP WOBURN MA

Personal Author(s) : Paika, Inder J.

PDF Url : ADA303835

Report Date : FEB 1994

Pagination or Media Count : 31

Abstract : 1 3,3-Trinitroazetidine (TNAZ) was dissolved in corn oil and injected intraperitonealy daily into albino Swiss mice for 3 days at doses of 40, 20, 10, 5, and 1 mg/kg. TNAZ did not induce an increased number of micronucleated cells and is considered to have a negative response. The positive control substance, mitomycin C, induced a statistically significant number of micronucleated cells, whereas the negative control substance (corn oil), did not induce increased number of micronucleated cells in the maturing erythrocytes of mouse bone marrow cells. Therefore, TNAZ is considered non-mutagenic, under the test system and conditions employed in this study.

Descriptors :   *TOXICITY, *CELLS(BIOLOGY), *GENETICS, *BONE MARROW, *ALBINISM, TEST AND EVALUATION, CONTROL, RESPONSE, MICE, OILS, ERYTHROCYTES, CORN, SWITZERLAND.

Subject Categories : Toxicology
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE