Accession Number : ADA304117

Title :   Outcome After Prophylactic Mastectomy in Individuals at High Risk for Breast Cancer: A Combined Clinical-Biological Study.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : MAYO FOUNDATION ROCHESTER MN

Personal Author(s) : Hartmann, Lynn ; Jenkins, Robert

PDF Url : ADA304117

Report Date : 01 SEP 1995

Pagination or Media Count : 58

Abstract : Both the clinical and laboratory phases of this work are proceeding on schedule. We have reviewed the medical records of 782 individuals, confirming that 92 percent of them indeed had a mastectomy performed with prophylactic intent. The acquisition of complete risk factor information and important clinical follow-up data (specifically the occurrence of breast and non-breast cancer in these high-risk individuals) is underway via medical record review and patient/next of kin follow-up questionnaire. In this initial phase, prior to complete documentation with outside records, 14 potential cases of breast cancer following prophylactic mastectomy have been identified. The laboratory investigators have developed appropriate screening methods for the ascertainment of BRCA1 mutations and several mutations have been identified. We have also developed techniques for the analysis of small breast lesions found in archival paraffin-embedded specimens, including atypia and lobular carcinoma in situ.

Descriptors :   *CLINICAL MEDICINE, *NEOPLASMS, *MAMMARY GLANDS, *BREAST CANCER, RISK, ACQUISITION, MUTATIONS, PHASE, MEDICINE, LABORATORIES, RECORDS, LESIONS, CANCER.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE