Accession Number : ADA304357

Title :   Cellular Analysis of the Startle Reflex (FY91 AASERT).

Descriptive Note : Final rept. 1 Sep 92-31 Aug 95,

Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s) : Davis, Michael

PDF Url : ADA304357

Report Date : JAN 1996

Pagination or Media Count : 6

Abstract : During the last two years we have be evaluating the role of the olivary cochlear bundle in some of these effects. We have found that local infusion into the olivary complex of lidocaine, a local anesthetic, leads to an increase in the amplitude of the compound action potential generated by an auditory stimulus recorded at the level of the cochlear nucleus. This suggests that the olivary cochlear bundle tonically inhibits auditory transmission at the level of the hair cells. Conversely, local application of kainate acid, which at very low doses activates cells, leads to a decrease in the compound action potential, consistent with an inhibitory role of the olivary cochlear system. Other drugs, such as pentazozine, that are known to act at the level of the outer hair cells, have opposite effects on the compound action potential in animals with an intact vs. a transected olivary cochlear bundle.

Descriptors :   *COCHLEA, *ANESTHETICS, *NUCLEI(BIOLOGY), *COCHLEAR NERVE, CELLS, TRANSMITTANCE, ANIMALS, EXTERNAL, DRUGS, INHIBITION, HEARING, LOCAL ANESTHETICS, BUNDLES, INFUSIONS, HAIR.

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE