Accession Number : ADA304478

Title :   The Role of CCAAT/Enhancer Binding Proteins in Mammary Tumor Promotion.

Descriptive Note : Annual rept. 15 Jul 94-14 Jul 95,

Corporate Author : OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s) : DeWille, James W.

PDF Url : ADA304478

Report Date : 14 AUG 1995

Pagination or Media Count : 14

Abstract : This annual report documents our progress in the initial phase of our study of the influence of diet on CCAAT/Enhancer binding proteins (C/EBPs) in mammary tissue. Our goal is to determine if chronic high fat or excess caloric intake alters C/EBP subcellular localization or DNA binding activity and the relationship between this diet-induced effect on mammary tumorigenesis. Diet-induced alterations in C/EBPs could provide a biochemical link between diet and mammary tumor promotion. Female MMTV/c-neu transgenic mice and nontransgenic controls are being fed 5% or 20% fat (w/w) diets ad libium or at 20% caloric restriction (four diets total). The data in this report demonstrate the influence of the diets on body weights after 2 months of feeding. The results indicate that there is no difference in bod weights between the ad libitum fed groups (Diet 1 vs 2). The body weights of both ad libitum fed groups ar statistically greater than the restricted fed groups (Diets 3 & 4). At this point in the study, the body weights o group 4 are greater than group 3. Mammary tumors develop in these mice at about 6 months of age, therefore we have not detected any tumors at this point in the study. The in vivo feeding and tumor incidence phase of th study will be completed by November 1995.

Descriptors :   *NEOPLASMS, *DIET, *BODY WEIGHT, *MAMMARY GLANDS, *CALORIFIC VALUE, *BREAST CANCER, PROTEINS, DEOXYRIBONUCLEIC ACIDS, FATS, MICE, IN VIVO ANALYSIS, FEEDING.

Subject Categories : Medicine and Medical Research
      Food, Food Service and Nutrition

Distribution Statement : APPROVED FOR PUBLIC RELEASE