Accession Number : ADA304581

Title :   Environmental Risk Assessments Based on Bone Marrow Cell Kinetic.

Descriptive Note : Technical rept. 31 Dec 93-31 Mar 94,

Corporate Author : OAK RIDGE NATIONAL LAB TN

Personal Author(s) : Jones, Troyce D. ; Morris, Max D. ; Hasan, Jafar S.

PDF Url : ADA304581

Report Date : 01 FEB 1996

Pagination or Media Count : 131

Abstract : Risk of acute mortality from ionizing radiations, leukemia, and cancer are modeled for exposures to X-rays, photons, fission-produced neutrons, and neutrons produced by thermonuclear processes. Risks from protracted exposures are evaluated in terms of sublethal injury to cells, repair of sublethal injury, I-hit cell killing, killing of cells having unrepaired sublethal injury, and radiation-induced cellular repopulation. These cellular effects can be used to equate the protracted exposure to a prompt or pulse exposure of a reference radiation such as through a calculated value for the Equivalent Prompt Dose (EPD). Model coefficients are given for hematopoietic stem cells, marrow stromal cells, and four representative line of human leukemia and lymphoma cells. A user-friendly, menu-driven, personal computer executable file named MarCell (for marrow cell) is included with this report.

Descriptors :   *X RAYS, *CELLS(BIOLOGY), *IONIZING RADIATION, *BONE MARROW, *CANCER, *LEUKEMIA, RADIATION, RISK, EXPOSURE(GENERAL), MODELS, HUMANS, REPAIR, PULSES, COEFFICIENTS, DOSAGE, PHOTONS, WOUNDS AND INJURIES, KINETICS, MICROCOMPUTERS, MORTALITY RATE, NEUTRONS, ENVIRONMENTAL IMPACT STATEMENTS, HEMATOPOIETIC CELLS, BLOOD CELLS, LYMPHOMAS, SUBLETHAL DOSAGE, THERMONUCLEAR REACTIONS.

Subject Categories : Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE