Accession Number : ADA305752

Title :   In Vitro Approach To Predictive Toxicokinetics.

Descriptive Note : Final rept. 1 Dec 94-30 Nov 95,

Corporate Author : WRIGHT STATE UNIV DAYTON OH DEPT OF PHARMACOLOGY

Personal Author(s) : Frazier, John M.

PDF Url : ADA305752

Report Date : 30 NOV 1995

Pagination or Media Count : 12

Abstract : The overall objective of this research program is to develop new approaches to predict the systemic toxicokinetics of chemicals utilizing in vitro experimental model systems and biologically-based kinetic (BBK) models. The focus of the proposed research is to test the hypothesis that in vitro measurements of membrane transport parameters in hepatic membrane vesicles are predictive of hepatic transport in vivo. Although this study is focused on transport processes in one particular organ, i.e. hepatic transport processes, these processes are a major controlling factor in determining systemic kinetics of many chemicals, particularly those which do not satify the 'perfusion limited' condition usually assumed in many current PBPK models.

Descriptors :   *TOXICITY, *IN VITRO ANALYSIS, MEASUREMENT, CHEMICALS, PARAMETERS, TRANSPORT PROPERTIES, TRANSPORT, MEMBRANES, KINETICS, HYPOTHESES, LIVER, IN VIVO ANALYSIS, ORGANS(ANATOMY), PERFUSION.

Subject Categories : Anatomy and Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE