Accession Number : ADA305889

Title :   Genetic Evidence of Early Breast Cancer.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95

Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES

Personal Author(s) : Shibata, Darryl

PDF Url : ADA305889

Report Date : OCT 1995

Pagination or Media Count : 10

Abstract : The earliest phases of breast cancer are poorly characterized. A precise understanding of the genetic changes which herald incipient transformation would be invaluable for accurate early diagnosis and a better understanding of its pathogenesis. Towards this goal, we aim to identify clonal breast populations based on the detection of only one X-chromosome androgen receptor allele after differential methylation sensitive restriction enzyme digestion. Although this analysis is suitable for large amounts of DNA, it was not reliable when small cell numbers were analyzed. Since the earliest breast cancer lesions are small, we have yet to develop a suitable assay for their analysis. However, new efforts based on technical improvements show promise for both high sensitivity and reliability.

Descriptors :   *CHROMOSOMES, *DIAGNOSIS(MEDICINE), *GENETICS, *MAMMARY GLANDS, *BREAST CANCER, DETECTION, CELLS, ACCURACY, POPULATION, DEOXYRIBONUCLEIC ACIDS, RELIABILITY, DIAGNOSIS(GENERAL), NUMBERS, PATHOGENESIS, LESIONS, CANCER, SURGICAL IMPLANTATION, HIGH SENSITIVITY.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE