Accession Number : ADA306015

Title :   Blood Amplification: Use of Phosphoenolpyruvate (PEP) Treated Red Blood Cell Transfusions in the Dog (Canis familiaris).

Descriptive Note : Final rept. 3 Aug 94-29 Feb 95,

Corporate Author : BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TX

Personal Author(s) : Cornum, Rhonda L.

PDF Url : ADA306015

Report Date : FEB 1996

Pagination or Media Count : 19

Abstract : Theoretically, decreasing hemoglobin oxygen affinity (HOA) of red blood cells (RBC) prior to transfusion should augment oxygen consumption during anemic hypoxia. Incubation of RBCs with phospenolpyruvate (PEP) increases 2,3-DPG and decreases HOA. This study evaluated the effect of transfusion with PEP treated RBCs on cardiovascular compensation and oxygen consumption in acutely anemic dogs.

Descriptors :   *HEMOGLOBIN, *CARDIOVASCULAR SYSTEM, *DOGS, *BLOOD TRANSFUSION, *BLOOD CELLS, RED(COLOR), HYPOXIA, INCUBATION, AMPLIFICATION, COMPENSATION, BLOOD, ANEMIAS, OXYGEN CONSUMPTION, HEMORRHAGIC SHOCK.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE