Accession Number : ADA306150

Title :   Immunotoxicity of Jet Fuel.

Descriptive Note : Final rept. 1 Oct 94-31 Oct 95,

Corporate Author : ARIZONA UNIV TUCSON

Personal Author(s) : Harris, David T.

PDF Url : ADA306150

Report Date : 31 OCT 1995

Pagination or Media Count : 23

Abstract : During our preliminary year of experimentation we have made an initial examination Off the immunotoxicological effects of JP-8 jet fuel exposure. Inbred C57BL6 mice were exposed to varying concentrations (either 500, 1000 or 2500 mg/m3) of aerosolized JP-8 jet fuel for a period of 7 days with an exposure period of 1 hour per day. Animal exposure was performed via nose-only presentation while the animals were held in individual subject loading tubes. The tubes were nose cone fitted to receiving adapters that originated from a common anodized aluminum exposure chamber. Nose only exposure was utilized to minimize ingestion of jet fuel during self grooming. Animals were rotated on a daily basis through the 12 adapter positions on the exposure chamber. This rotation was done to minimize proximity to the jet fuel source as a variable in exposure concentration or composition. Exposure concentration was determined by a seven stage --cascade impactor, and were measured after each exposure (1,2). 24 hours after the last exposure the animals were sacrificed and examined for changes in immune system composition and function. The major immune system organ systems (i.e., spleen, thymus, lymph nodes, blood and bone marrow) were recovered and examined for changes in organ weight total cell numbers, immune cell components (by differential histochemical staining).

Descriptors :   *TOXICITY, *EXPOSURE(PHYSIOLOGY), *IMMUNITY, *JET ENGINE FUELS, *ORGANS(ANATOMY), MAINTENANCE, SOURCES, EXPOSURE(GENERAL), CELLS, WEIGHT, ANIMALS, IMMUNOLOGY, ADAPTERS, NUMBERS, CHAMBERS, BONE MARROW, BLOOD, SPLEEN, NOSE CONES, LYMPH NODES, THYMUS.

Subject Categories : Toxicology
      Jet and Gas Turbine Engines

Distribution Statement : APPROVED FOR PUBLIC RELEASE