Accession Number : ADA306180

Title :   Functional Diversity Interacting Reactors.

Descriptive Note : Final rept. 1 Aug 94-31 Jul 95,

Corporate Author : NEW YORK ACADEMY OF SCIENCES NY

Personal Author(s) : Lajtha, Abel ; Abood, Leo G.

PDF Url : ADA306180

Report Date : AUG 1995

Pagination or Media Count : 555

Abstract : The Functional Diversity of Interacting Receptors Conference was sponsored by the New York Academy of Sciences and held in Washington, D.C. on May 25-28,1994. The conference was chaired by Abel Lajtha, Ph.D., Center for Neurochemistry, Nathan S. Kline Institute, and Leo Abood, Ph.D., Department of Pharmacology, University of Rochester. Approximately 80 researchers and clinicians attended. Attendees came from throughout the United States and Europe. The conference focused on the functional significance of receptor diversity, by addressing the genetic regulation and expression of receptor subtypes; the differential functional characteristics of neurons with distinct subtypes; second messenger and ion channel diversity associated with receptor isoforms; species and regional neuroanatomic differences in receptor subtypes; receptor changes associated with chronic exposure to agonists and antagonists and occurring with age and pathologic states; and the interaction of different receptors in functional regulation. Since our knowledge of the structural, genetic, and functional features of the nicotinic cholinergic receptors appears to be more advanced than that of other receptors, the emphasis of the conference was on cholinergic receptors and their interaction with other receptors. Also included were presentations dealing with adrenergic, dopaminergic, histaminergic, gabaminergic, excitatory amino acid, and peptidergic receptors and their interactions and functional implications in health and disease.

Descriptors :   *NERVE CELLS, *CHOLINERGIC NERVES, *ACETYLCHOLINE, *MUSCARINE, *NICOTINIC ACID, EUROPE, CONTROL, IONS, UNITED STATES, EXPOSURE(GENERAL), NEUROCHEMISTRY, NEUROTRANSMITTERS, CHANNELS, GENETICS, SENSE ORGANS, RECEPTOR SITES(PHYSIOLOGY), AMINO ACIDS, PHARMACOLOGY.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE