Accession Number : ADA306183

Title :   Psychophysiological Reactivity and Immunological Sensitivity to Stress in Healthy Women at Familial Risk for Breast Cancer.

Descriptive Note : Annual rept. 1 Jan-31 Dec 95,

Corporate Author : SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s) : Zakowski, Sandra G. ; Bovbjerk, Dana H.

PDF Url : ADA306183

Report Date : JAN 1996

Pagination or Media Count : 12

Abstract : As of December 1995, 64 women with and without family histories of breast cancer have completed the first assessment of the proposed study. Of these, 38 have returned for the second experimental assessment. Subjects are exposed to 2 consecutive tasks designed to induce stress in a laboratory serting. Their psychophysiological and immune responses are assessed during and after stress' exposure and compared to their own resting baseline for reactivity assessments. Questionnaires measuring background information and chronic stress are also administered. Initial observations confirm that the experimental tasks are stressful and elicit marked immune changes which are in accordance with previously published data. Statistical analyses addressing the main hypotheses concerning contribution of family history of cancer to psychophysiological reactivity and immunological sensitivity to stress will be conducted upon completion of data collection as planned by the end of 1996.

Descriptors :   *HEALTH, *STRESS(PHYSIOLOGY), *SENSITIVITY, *MAMMARY GLANDS, *PSYCHOPHYSIOLOGY, *BREAST CANCER, STRESSES, RISK, REACTIVITIES, DATA ACQUISITION, STATISTICAL ANALYSIS, HYPOTHESES, IMMUNOLOGY, IMMUNITY, WOMEN, QUESTIONNAIRES, CANCER, ADDRESSING.

Subject Categories : Medicine and Medical Research
      Personnel Management and Labor Relations
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE