Accession Number : ADA306474

Title :   Estrogen Metabolism and Familial Risk of Breast Cancer.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES SCHOOL OF MEDICINE

Personal Author(s) : Ursin, Giske

PDF Url : ADA306474

Report Date : OCT 1995

Pagination or Media Count : 9

Abstract : It has been suggested that women who metabolize a larger proportion of their natural estrogen via the 16%-hydroxy pathway may be at significantly elevated risk of breast cancer compared to women who metabolize proportionally more estrogen via the 2-hydroxy pathway. This study evaluates whether the ratios of 16a-OHEl to 2-OHEl are higher in urine of premenopausal women at 'high' than at 'low' familiar risk of breast cancer; and whether the ratio is elevated in cases independent of total urinary estrone (E1), estradiol (E2) and estriol (E3). Early morning urine samples are collected from 100 premenopausal women at 'high' and 100 premenopausal women at 'low' risk of breast cancer. All subjects are sisters or daughters of subjects participating in one of three case-control studies of breast cancer at our institution. Five estrogen metabolites in urine are determined: 1 6a-OHE 1, OHE 1, El, E2 and E3 conjugates. The data collection is in progress.

Descriptors :   *RISK, *METABOLISM, *MAMMARY GLANDS, *ESTROGENS, *BREAST CANCER, RATIOS, DATA ACQUISITION, WOMEN, METABOLITES, URINE, CANCER.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE