Accession Number : ADA307404

Title :   Neurophysiological Analysis of Circadian Rhythm Entrainment.

Descriptive Note : Final rept. 1 Jan 93-31 Jan 96,

Corporate Author : DALHOUSIE UNIV HALIFAX (NOVA SCOTIA) DEPT OF PSYCHOLOGY

Personal Author(s) : Rusak, Benjamin

PDF Url : ADA307404

Report Date : 31 JAN 1996

Pagination or Media Count : 13

Abstract : This program of research identified a number of novel roles for peptides and neurotransmitters found in the suprachiasmatic nuclei (SCN), in the regulation of SCN neuronal activity and behavioral circadian rhythms. Major findings included the observations of changes in SCN cell firing rates and behavioral phase shifts induced by gastrin releasing peptide (GRP) when applied to SCN cells. GRP was demonstrated not to act primarily in concert with other peptides in a manner proposed by an earlier publication. Similar combinations of neurophysiological and behavioral studies have been completed using another peptide, substance P, and are partially completed using VIP. Other studies have investigated the neurophysiological role of metabotropic glutamate receptors, and the behavioral effects of their activation or blockade. Neurophysiological studies investigated the effects of melatonin and of serotonin on photic responses of SCN cells and evaluated putative antagonists for these effects. Antagonists that acted selective on the melatonin and serotonin receptors in the sCN were identified. Additional studies examining the neurophysiological effects of opiatergic drugs, histamine and redox agents were also completed.

Descriptors :   *CIRCADIAN RHYTHMS, *PEPTIDES, *NEUROTRANSMITTERS, *NEUROPHYSIOLOGY, *BEHAVIORAL SCIENCES, ACTIVATION, CELLS, RELEASE, BEHAVIOR, DRUGS, ENTRAINMENT, OXIDATION REDUCTION REACTIONS, PHASE SHIFT, MOTOR NEURONS, HISTAMINE, FIRING RATE, MELATONIN, GASTRIN.

Subject Categories : Anatomy and Physiology
      Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE