Accession Number : ADA307632

Title :   Attenuated VEE Vaccine Vectors Expressing HIV Immunogens.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s) : Johnston, Robert E.

PDF Url : ADA307632

Report Date : SEP 1995

Pagination or Media Count : 47

Abstract : A series of expression vectors based on attenuated vaccine strains of Venezuelan equine encephalitis virus (VEE) have been constructed with the ultimate goal of expressing immunizing antigens derived from HIV- 1 in vivo, thus protecting against subsequent exposure to HIV. To that end we have constructed four such vectors and expressed HIV-l matrixicapsid, gpi6O and gpl2o in cell culture and in rodent models. Analogous constructs expressing SIV immunogens also have been generated. These are being evaluated in rodent models in preparations for primate trials.

Descriptors :   *STRAINS(BIOLOGY), *IN VIVO ANALYSIS, *ANTIGENS, *VACCINES, *DISEASE VECTORS, *VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, PREPARATION, MODELS, RODENTS, HUMAN IMMUNODEFICIENCY VIRUSES, CELLS(BIOLOGY), IMMUNIZATION, CULTURES(BIOLOGY), IMMUNOGENS.

Subject Categories : Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE