Accession Number : ADA308304

Title :   Inhalation Uptake and Metabolism of Halon 1301 Replacement Candidates, HFC-227 ea, HFC-125, and FC-218.

Descriptive Note : Interim rept. Mar-Dec 94,

Corporate Author : ARMSTRONG LAB BROOKS AFB TX OCCUPATIONAL AND ENVIRONMENTAL HEALTH DIRECTORATE

Personal Author(s) : Creech, J. R. ; Black, R. K. ; Neurath, S. K. ; Williams, R. J. ; Jepson, G. W.

PDF Url : ADA308304

Report Date : FEB 1995

Pagination or Media Count : 55

Abstract : The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of bromotrifluoromethane's (Halon 1301) proposed replacement chemicals HFC-227ea, HFC-125, and FC-218. Parallel information pertaining to Halon 1301 and CF(3)I can be found in AL/OE-TR-1994-0068. Tissue to air partition coefficients were determined using the vial equilibration method (Gargas et al., 1989). Inhalation pharmacokinetics for all Halon 1301 replacements were determined experimentally in Fischer 344 (F-344) male rats via a closed chamber recirculating gas uptake methods (Gargas et al., 1986). A physiologically-based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these experiments. Using these techniques, no metabolism of these chemicals were detected in Fischer 344 rats.

Descriptors :   *KINETICS, *PHARMACOKINETICS, *FIRE EXTINGUISHING AGENTS, *HALOGENATED HYDROCARBONS, *INHALATION, RATS, DISTRIBUTION, AIR, CHEMICALS, METABOLISM, COEFFICIENTS, CONSTANTS, MALES, PARALLEL ORIENTATION.

Subject Categories : Toxicology
      Pharmacology
      Safety Engineering

Distribution Statement : APPROVED FOR PUBLIC RELEASE