Accession Number : ADA308311

Title :   Long-Term Potentiation: Role of Hippocampal Adrenal Steroid Type I and Type II Receptors in the Diurnal Rhythm and the Impact of Stress.

Descriptive Note : Final rept. 1 Dec 92-30 Nov 95,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : McEwen, Bruce S. ; Magarinos, Ana M. ; Pavlides, Constantine

PDF Url : ADA308311

Report Date : 11 APR 1996

Pagination or Media Count : 11

Abstract : Adrenal steroids are secreted during stress, but also show diurnal rhythmicity during the sleep-wake cycle. It has become evident, in the past several years, that adrenal steroids can affect brain function and in particular cognitive processes. Thus, both stress or shifts of the diurnal cycle, which can occur with shifts in work schedule or jet lag, commonly experienced by military personnel in general and aviators and air crews in particular, can have major consequences for human performance. To provide a basis for understanding environmental control of human performance, the main goal of this project was to investigate effects of adrenal steroids on synaptic plasticity in the hippocampus, a brain structure which contains the highest concentration of adrenal steroid receptors, and which is closely associated with episodic and spatial learning and memory. The model of neuronal plasticity used to investigate these processes was LTP and LTD, the majority of the studies were performed in vivo. Furthermore, the molecular mechanisms that may accompany the physiological changes were also investigated.

Descriptors :   *STRESS(PHYSIOLOGY), *IN VIVO ANALYSIS, *HIPPOCAMPUS, *STEROIDS, *BIOLOGICAL RHYTHMS, STRESSES, CONTROL, FUNCTIONS, SPATIAL DISTRIBUTION, MILITARY PERSONNEL, ENVIRONMENTS, IMPACT, BRAIN, MODELS, FLIGHT CREWS, PERFORMANCE(HUMAN), COGNITION, PILOTS, CYCLES, SCHEDULING, WAKE, PLASTIC PROPERTIES, NERVE CELLS, PHYSIOLOGY, SYNAPSE, LEARNING, MOLECULAR PROPERTIES, DIURNAL VARIATIONS, SLEEP, ADRENAL GLANDS.

Subject Categories : Pharmacology
      Medicine and Medical Research
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE