Accession Number : ADA308744

Title :   Effects of Melatonin on Diurnal Mood.

Descriptive Note : Final rept. Jan 92-Jan 93,

Corporate Author : ARMSTRONG LAB BROOKS AFB TX CREW SYSTEMS DIRECTORATE

Personal Author(s) : Stoner, Paul S., Jr. ; French, Jonathan ; Hughes, Rodney J. ; Whitmore, Jeffrey N.

PDF Url : ADA308744

Report Date : MAR 1996

Pagination or Media Count : 26

Abstract : As a substance produced nocturnally by the pineal gland, melatonin may have utility in promoting sleep during diurnal or other unusual sleep periods. Oral doses (100 mg and 10 mg) of melatonin were used to evaluate effects on diurnal mood and oral temperature. The six subjects in the experiment were male volunteers (range 20-42 years old). Oral temperature, plasma and salivary melatonin samples were obtained every 2 hours beginning at 0800 until 1700. A significant correlation (r =0.74) occurred between plasma and salivary melatonin samples. Temperature effects, subjective fatigue and confusion scores were increased by the 100 mg dose within 3-4 hours after dosing. Salivary levels of melatonin may be used as a non-invasive measure of plasma melatonin. As a substance produced endogenously, melatonin may make useful non-addictive soporific devoid of typical sedative side effects. As a substance produced nocturnally by the pineal gland, melatonin may have utility in promoting sleep during diurnal or other unusual sleep periods. Oral doses (100 mg and 10 mg) of melatonin were used to evaluate effects on diurnal mood and oral temperature. The six subjects in the experiment were male volunteers (range 20A2 years old). Oral temperature, plasma and salivary melatonin samples were obtained every 2 hours beginning at 0800 until 1700. A significant correlation (r =0.74) occurred between plasma and salivary melatonin samples. Temperature effects, subjective fatigue and confusion scores were increased by the 100 mg dose within 3-4 hours after dosing. Salivary levels of melatonin may be used as a non-invasive measure of plasma melatonin. As a substance produced endogenously, melatonin may make useful non-addictive soporific devoid of typical sedative side effects.

Descriptors :   *CIRCADIAN RHYTHMS, *FATIGUE(PHYSIOLOGY), *SALIVA, *PINEAL GLAND, MEASUREMENT, TEMPERATURE, HORMONES, PLASMAS(PHYSICS), VOLUNTEERS, TIME, SAMPLING, SEROTONIN, MALES, SLEEP DEPRIVATION, SCORING, ORAL DOSAGE, ORAL INTAKE, SLEEP, NEUROPHYSIOLOGY, TRYPTOPHAN, MELATONIN.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE