Accession Number : ADA309257

Title :   Synthesis of Chiral Pyridine-Based Macrobicyclic Clefts.

Descriptive Note : Technical rept.,

Corporate Author : BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY

Personal Author(s) : Hellier, Paul C. ; Bradshaw, Jerald S. ; Izatt, Reed M.

PDF Url : ADA309257

Report Date : MAY 1996

Pagination or Media Count : 19

Abstract : An achiral (3) and two chiral pyridine-based macrobicyclic clefts (4 and 5) have been prepared by treating 2,6-bis(2',6'-bis(bromomethyl)-4'- methylphenoxymethyl)pyridine (2) with the appropriate achiral and chiral glycols. Starting 2 was prepared by first treating 2,6- bis(hydroxymethyl)-4-methylphenol with 2,6-pyridinedimethyl ditosylate followed by phosphorus tribromide.

Descriptors :   *SYNTHESIS(CHEMISTRY), *PYRIDINES, METHYL RADICALS, ORGANIC COMPOUNDS, PHOSPHORUS, PHENOLS, BROMINE, GLYCOLS.

Subject Categories : Organic Chemistry
      Inorganic Chemistry
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE