Accession Number : ADA309257
Title : Synthesis of Chiral Pyridine-Based Macrobicyclic Clefts.
Descriptive Note : Technical rept.,
Corporate Author : BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY
Personal Author(s) : Hellier, Paul C. ; Bradshaw, Jerald S. ; Izatt, Reed M.
PDF Url : ADA309257
Report Date : MAY 1996
Pagination or Media Count : 19
Abstract : An achiral (3) and two chiral pyridine-based macrobicyclic clefts (4 and 5) have been prepared by treating 2,6-bis(2',6'-bis(bromomethyl)-4'- methylphenoxymethyl)pyridine (2) with the appropriate achiral and chiral glycols. Starting 2 was prepared by first treating 2,6- bis(hydroxymethyl)-4-methylphenol with 2,6-pyridinedimethyl ditosylate followed by phosphorus tribromide.
Descriptors : *SYNTHESIS(CHEMISTRY), *PYRIDINES, METHYL RADICALS, ORGANIC COMPOUNDS, PHOSPHORUS, PHENOLS, BROMINE, GLYCOLS.
Subject Categories : Organic Chemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE