Accession Number : ADA309899

Title :   Dose-Response Correlation of Methadone and its Metabolite EDDP in Human Hair. Completion of the Second and Preparation of the Third Test Series.

Descriptive Note : Technical rept. no. 5, 1 Nov-31 Dec 95,

Corporate Author : NAVAL RESEARCH LAB WASHINGTON DC

PDF Url : ADA309899

Report Date : 31 DEC 1995

Pagination or Media Count : 2

Abstract : Analogous to the first test series, the following steps were undertaken with each of the subjects of the Methadone distribution center in Saarbruecken: (a) Five sweat patches were applied and then removed after one, two, three, four, and six days respectively. Contrary to the patients of Dr. Franta's practice, none of the subjects complained about allergic reactions or irritations. Yet, several of the sweat patches were lost, and a few subjects commented on poor adhesion of the patches to their skin. (b) One strand of hair was bleached and simultaneously, another unbleached strand was removed as a reference. The bleaching procedure was performed with a conventional hair bleaching - - agent over a distance of at least 1 cm from the scalp. The bleaching agent was kept on the hair strand for 45 minutes and was then washed out with shampoo. (c) After four weeks the bleached hair strand as well as an unbleached agent was kept on the hair strand (for reference) were removed.

Descriptors :   *SKIN(ANATOMY), *METABOLITES, *GROWTH(PHYSIOLOGY), *ALLERGIC DISEASES, *HAIR, HUMANS, ADHESION, PATIENTS, RESPONSE(BIOLOGY), HEAD(ANATOMY), DOSE RATE, STRANDS, BLOOD, BLEACHING AGENTS, BLOOD ANALYSIS.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE