Accession Number : ADA311312

Title :   Biosensor-Based Detection and Verification System for Blo-Chemical Warfare Agents, Appendices 1, 2 and 3.

Descriptive Note : Final rept. 9 Jun 91-9 Jun 96,

Corporate Author : MOLECULAR DEVICES CORP SUNNYVALE CA

Personal Author(s) : Owicki, John C.

PDF Url : ADA311312

Report Date : 08 JUL 1996

Pagination or Media Count : 178

Abstract : The purpose of this contract was to explore and demonstrate the application of technology based on the Light Addressable Potentiometric Sensor (LAPS) to detection and verification problems for bio-chemical warfare agents. The principal analytical method employed was microphysiometry, by which perturbations of cell physiology are detected using the LAPS. The work was done in three principal segments. First, silicon microtechnology was used to design and fabricate sensor chips and microfluidic components suitable for the project. Second, a systems- engineering effort designed and assembled a prototype high-performance microphysiometer. Third, a biological effort employed a wide variety of cellular and ligand-receptor model systems to validate the generality of the method and the performance of the prototype instrument.

Descriptors :   *COMPUTER PROGRAMS, *LIGHT, *BIOLOGICAL WARFARE AGENTS, *CHEMICAL WARFARE AGENTS, *POTENTIOMETRIC ANALYSIS, *BIOLOGICAL AGENT DETECTORS, VERIFICATION, PERFORMANCE(ENGINEERING), CELLS, BIOCHEMISTRY, CHIPS(ELECTRONICS), PROTOTYPES, SILICON, LIGANDS, COMPUTER APPLICATIONS, PERTURBATIONS, PHYSIOLOGY, ADDRESSING.

Subject Categories : Biochemistry
      Computer Programming and Software
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE