Accession Number : ADA311562

Title :   Propofol and Fentanyl Compared to Midazolam and Fentanyl During Third Molar Surgery.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : Parworth, Larry P.

PDF Url : ADA311562

Report Date : 1996

Pagination or Media Count : 54

Abstract : Fifty-seven patients undergoing removal of third molars with intravenous sedation between November 1994 and December 1995 randomly received either propofol and fentanyl (P + F) or rnidazolam and fentanyl (M + F). Twenty-four received P + F and thirty-three received M + F. Pre-operatively, patient demographics, Corah anxiety scores and physiologic parameters were obtained. Ml patients were titrated to the same endpoint for sedation. Intra-operative physiologic parameters, cooperation, alertness and pain scores were assessed. Post-operative recovery and degree of amnesia were determined. There were no statistically significant differences in patient demograhpics and surgical characteristics between groups. The P + F group was statistically significantly less cooperative than the M + F group. Pain during injection of propofol was a significant adverse side effect. Both groups experienced a small percentage of apneic episodes but mechanical ventilation was never required. There was no difference in recovery between groups as assessed by Treiger dot test and psychomotor recovery scores. The degree of retrograde amnesia was higher for the M + F group although the differences were not statistically significant. Sedation was rated good to excellent by the patient, surgeon and observer and there were no statistically significant differences between groups. Propofol appears to be a safe and efficacious drug for use in outpatient oral surgical procedures.

Descriptors :   *MEDICAL SERVICES, *SURGERY, *ANESTHESIA, *SURGEONS, MECHANICAL PROPERTIES, RECOVERY, PARAMETERS, VENTILATION, ADVERSE CONDITIONS, PHYSIOLOGY, PAIN, PATIENTS, OUTPATIENT CLINICS, PHYSICIANS, ATTENTION, SCORING, VEINS, ORAL INTAKE, PSYCHOMOTOR TESTS, ORAL HEALTH, ANXIETY, AMBULANCES, AMNESIA, ORAL HYGIENE, MAXILLA, SEDATION.

Subject Categories : Personnel Management and Labor Relations
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE