Accession Number : ADA311660

Title :   Molecular Detection of Breast Cancer.

Descriptive Note : Annual rept. 9 Jan 95-8 Jan 96,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Clarke, Michael F.

PDF Url : ADA311660

Report Date : FEB 1996

Pagination or Media Count : 34

Abstract : Breast cancer is the second leading cause of cancer death among American women, with over 170,000 new cases and 50,000 deaths each year. Despite advances in detection and treatment, mortality from these diseases remains high. Traditional modes of treatment including radiation therapy, chemotherapy, and hormonal therapy have been useful, but are limited by the emergence of treatment-resistant cancer cells. Clearly new approaches are needed to treat these diseases. This project is designed to develop novel approaches to detect breast cancer cells that contaminate peripheral blood and bone marrow, and to remove such contaminating cells. An RT-PCR assay has been developed to detect breast cancer cells, and a novel gene therapy vector has been developed to kill contaminating cancer cells. Blood and bone marrow samples obtained from patients with breast cancer are being collected. These samples will be analyzed to determine whether the K19 RT-PCR assay can be used to predict outcome.

Descriptors :   *MOLECULAR BIOLOGY, *CHEMOTHERAPY, *BREAST CANCER, ARMY RESEARCH, SURVIVABILITY, TOXICITY, IN VITRO ANALYSIS, BIOLOGICAL CONTAMINATION, MONOCLONAL ANTIBODIES, MEDICAL RESEARCH, IN VIVO ANALYSIS, WOMEN, BONE MARROW, ADENOVIRUSES, MICROBIOLOGY, MAMMARY GLANDS, IMMUNOCHEMISTRY, HEMATOPOIETIC CELLS, CHEMOTHERAPEUTIC AGENTS, BLOOD CELLS, SURGICAL TRANSPLANTATION, HISTOLOGICAL TECHNIQUES, ESTROGENS, METASTASIS, MITOSIS, NEUROBLASTOMA, OCCULTATION, RADIOTHERAPY.

Subject Categories : Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE