Accession Number : ADA312047

Title :   Role of Accessory Molecule in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.

Descriptive Note : Annual rept. 1 Jun 94-31 May 95,

Corporate Author : MARYLAND UNIV BALTIMORE

Personal Author(s) : Goldblum, Simeone E.

PDF Url : ADA312047

Report Date : 30 JUN 1995

Pagination or Media Count : 23

Abstract : This grant has been renegotiated and the new technical objectives are: (1) To determine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.

Descriptors :   *BACTERIAL TOXINS, *ENDOTOXINS, *ENDOTHELIUM, *LIPOPOLYSACCHARIDES, *GRAM NEGATIVE BACTERIA, COUPLING(INTERACTION), FUNCTIONS, INTERACTIONS, MOLECULES, PROTEINS, ADHESION, SUBSTRATES, CELLS(BIOLOGY), DYSFUNCTION, HOSTS(BIOLOGY), TYROSINE, DISASSEMBLY, PHOSPHORYLATION.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE