Accession Number : ADA312047
Title : Role of Accessory Molecule in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.
Descriptive Note : Annual rept. 1 Jun 94-31 May 95,
Corporate Author : MARYLAND UNIV BALTIMORE
Personal Author(s) : Goldblum, Simeone E.
PDF Url : ADA312047
Report Date : 30 JUN 1995
Pagination or Media Count : 23
Abstract : This grant has been renegotiated and the new technical objectives are: (1) To determine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.
Descriptors : *BACTERIAL TOXINS, *ENDOTOXINS, *ENDOTHELIUM, *LIPOPOLYSACCHARIDES, *GRAM NEGATIVE BACTERIA, COUPLING(INTERACTION), FUNCTIONS, INTERACTIONS, MOLECULES, PROTEINS, ADHESION, SUBSTRATES, CELLS(BIOLOGY), DYSFUNCTION, HOSTS(BIOLOGY), TYROSINE, DISASSEMBLY, PHOSPHORYLATION.
Subject Categories : Biochemistry
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE