Accession Number : ADA312075

Title :   Potential Benefits and Hazards of Humoral Immune Reactions against HTLV-III.

Descriptive Note : Final rept. 30 Sep 86-29 Sep 89,

Corporate Author : KAROLINSKA INST STOCKHOLM (SWEDEN)

Personal Author(s) : Wigzell, Hans

PDF Url : ADA312075

Report Date : OCT 1989

Pagination or Media Count : 19

Abstract : Monoclonal murine IgG antibodies against Gp120 from HIV-1 were found to induce significant enhancement of HIV-1 replication in vitro when used at low antibody concentrations. This enhancement was dependent on the presence of FcR:s for IgG and was completely blocked by anti-CD4 monoclonal antibodies. HIV-1 seropositive individuals at a low frequency do produce antibodies reactive with Gp12O and 'mimicking' CD4 molecules as evidenced by their reactivity with certain CD4 monoclonal antibodies. It was, however, not possible to show that such 'mimicking' antibodies were especially efficient in neutralizing, nor was presence of such antibodies linked to a particular clinical progression behaviour. Presence of antibodies to peptides covering the respective cysteins in the V3 loop of a particular HIV-1 isolate were found using two Italian cohorts to be positively linked to a reduced rate of transmission of virus from mother to child.

Descriptors :   *MONOCLONAL ANTIBODIES, *HUMAN IMMUNODEFICIENCY VIRUSES, *VACCINES, *ACQUIRED IMMUNE DEFICIENCY SYNDROME, *INFECTIOUS DISEASE TRANSMISSION, HAZARDS, PEPTIDES, RATES, REACTIVITIES, IN VITRO ANALYSIS, REDUCTION, LOW LEVEL, CONCENTRATION(COMPOSITION), ANTIBODIES, IMMUNOLOGY, INFECTIOUS DISEASES, VIRUSES, LINKAGES, BENEFITS, LOW FREQUENCY, SEROLOGY, HUMORAL IMMUNITY.

Subject Categories : Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE