Accession Number : ADA312794

Title :   Evaluation of the Mechanism of Immunosuppression and Calcium Homeostasis by an Immunosuppressive Trauma Peptide.

Descriptive Note : Final rept. 1 Jun 94-31 May 95,

Corporate Author : CALIFORNIA UNIV MEDICAL CENTER SAN DIEGO

Personal Author(s) : Hoyt, David B.

PDF Url : ADA312794

Report Date : NOV 1995

Pagination or Media Count : 5

Abstract : T-Cell suppressive factors (TSF) are thought to suppress host immunity and contribute to the development of sepsis. During the past year, we have investigated the relative roles of prostaglandin E2 (PGE2), Interleukin 4 (ITh-4), Interleukin 10 (IL-lO), and transforming growth factor %% (TGFE1) as immunosuppressive factors in our rabbit endotoxemia model. Endotoxemia suppresses in. vivo cell mediated immune function and increased PGE2, IL-4, IL-lO, and TGF% levels are measurable. Serum from these animals following endotoxemia suppresses T-cell proliferation and ITh-4, ITh-lO, TGF%, and PGE2 had TSF activities of 530, 102, 12, and .37 U/ng. TGF%, IL-lO, and TTh-4, contributed 37, 32, and 14 U/ml to a total serum TSF activity of 614 U%ml, while PGE2 contributed only .007 U/ml. These results show that TGF%1, IL-lO, IL-4, and other uncharacterized factors, are potent T-cell suppressors following rabbits. PGE is df much less Significance.

Descriptors :   *CALCIUM, *T LYMPHOCYTES, *IMMUNITY, *IMMUNOSUPPRESSION, *HOMEOSTASIS, *ENDOTOXEMIA, NUCLEAR PROLIFERATION, FUNCTIONS, CELLS, PEPTIDES, GROWTH(GENERAL), IN VIVO ANALYSIS, SUPPRESSION, TRAUMA, RABBITS, ANATOMICAL MODELS.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE