Accession Number : ADA313451
Title : The Effects Upon Structure of Optical Grade Polycarbonate of Various Protective Substances Applied to and Incorporated within It.
Descriptive Note : Final rept. 1 Jun 90-28 Feb 95,
Corporate Author : WALTER REED ARMY MEDICAL CENTER WASHINGTON DC
Personal Author(s) : Cavallaro, Brian E. ; Hollifield, Rodney D. ; Ward, Thomas P. ; Wertz, Fleming D.
PDF Url : ADA313451
Report Date : MAR 1995
Pagination or Media Count : 18
Abstract : We designed a study to determine the effects of intraocular fragments of ballistic protective lenses, laser protective frontserts, and the laser absorbing dyes employed in the BLPS system. The intraocular toxicity of polycarbonate, the laser absorbing dyes, and the scratch resistant coatings employed in BLPS are largely unknown. Knowledge of these potential toxicities is important in establishing medical evacuation priorities and surgical management. Fragments of the BLPS lenses, frontserts, and suspensions of the dyes were surgically implanted into the eyes of rabbits. The animals were randomized into ten groups including positive and negative controls. The animals were examined clinically and electrophysiologically prior to implantation and enucleation. They were euthanized at various intervals up to 26 weeks. Those eyes implanted with 3 lambda frontsert fragments exhibited supernormal dark-adapted ERG b-wave amplitudes. Intraocular inflammation was significaudy greater at early time points in both the clear polycarbonate and 3 lambda groups. Those eyes injected with lambda 1 and lambda 3 absorbing dyes exhibited depressed dark-adapted ERG b-wave amplitudes. We have developed a reliable and reproducible system for evaluating the intraocular toxicities of ballistic and laser protective eyewear. The lambda 1 and lambda 3 absorbing dyes appear to interfere with normal retinal physiology at one week. These changes are consistent with the apparent toxicity noted in the studies employing BLPS frontsert fragments in which the fragment containing all three dyes produced significant ERG abnormalities at 1 to 2 weeks.
Descriptors : *OPTICAL PROPERTIES, *PROTECTIVE EQUIPMENT, *EYE, *POLYCARBONATES, TOXICITY, RESISTANCE, LASERS, COATINGS, ABSORBERS(MATERIALS), ANIMALS, PHYSIOLOGY, RETINA, DYE LASERS, INFLAMMATION, REPRODUCIBILITY, FRAGMENTS, ABNORMALITIES, LENSES, IMPLANTATION, MEDICAL EVACUATION, RABBITS, EYEGLASSES.
Subject Categories : Polymer Chemistry
Ceramics, Refractories and Glass
Distribution Statement : APPROVED FOR PUBLIC RELEASE