Accession Number : ADA313658

Title :   Development of an Intravascular Biosensor for Plasma Glucose Monitoring During Hemorrhagic Shock.

Descriptive Note : Final rept. 10 Sep 93-10 Mar 96,

Corporate Author : NEW MEXICO UNIV ALBUQUERQUE DEPT OF CHEMICAL AND NUCLEAR ENGINEERING

Personal Author(s) : Wilkins, Ebtisam S.

PDF Url : ADA313658

Report Date : 10 MAR 1996

Pagination or Media Count : 141

Abstract : The main objective of this research project was the development of an intravenous glucose sensor which can be used to monitor and therapeutically prevent the onset of hypoglycemia in acute hemorrhagic shock. It has been shown that infusion of glucose at a rate sufficient to prevent the fall in glucose level slows or even arrests the decompensatory phase which will enhance the survival rate of wounded soldiers in battlefield settings. The extension of the compensatory phase is also of obvious utilization in civilian trauma management The goal of this project was to develop biosensor technology to better define hemorrhagic shock processes in order to optimize fluid resuscitation in trauma victims. Under this project The University of New Mexico studied a series of enzyme electrodes and biosensors, including a miniature needle-sized glucose biosensor suitable for intravenous glucose monitoring. The prototype of the biosensor developed shows a sufficient sensitivity over a wide range of linear response to glucose concentration, which covers the hypo and hyperglycemic conditions observed during the phases of hemorrhagic shock. The sensor was tested in vitro in model buffer solutions, blood plasma and whole blood, demonstrating response characteristics allowing in vivo glucose monitoring.

Descriptors :   *SURVIVAL(PERSONNEL), *IN VIVO ANALYSIS, *GLUCOSE, *HEMORRHAGIC SHOCK, *TRAUMATIC SHOCK, BUFFERS, DETECTORS, MANAGEMENT, MONITORING, ARMY PERSONNEL, ENZYMES, ARRESTING(PROCESS), PROTOTYPES, IN VITRO ANALYSIS, SOLUTIONS(GENERAL), RESPONSE, ELECTRODES, LINEARITY, CASUALTIES, FLUIDS, WOUNDS AND INJURIES, BIOLOGICAL DETECTION, RANGE(EXTREMES), COMPENSATION, BLOOD, VEINS, TRAUMA, BLOOD VESSELS, BLOOD PLASMA, RESUSCITATION, INFUSIONS, HYPOGLYCEMIA.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Escape, Rescue and Survival

Distribution Statement : APPROVED FOR PUBLIC RELEASE