Accession Number : ADA314088

Title :   Maternal Factors Influencing Perinatal Transmission of HIV Infection.

Descriptive Note : Final rept. 30 Sep 88-30 Sep 93,

Corporate Author : UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK

Personal Author(s) : Connor, Edward M. ; Oleske, James M.

PDF Url : ADA314088

Report Date : OCT 1993

Pagination or Media Count : 43

Abstract : The initial study design entailed a prospective evaluation of pregnant HIV infected women and their offspring over five years from September 1988 to September 1993. Mother-infant pairs were recruited into the study as early as possible during pregnancy with eligible pregnant women being enrolled after written informed consent was obtained. Enrolled women were followed at defined intervals during pregnancy, delivery, and postpartum. Infants born to enrolled mothers were assessed for the presence or absence of HIV infection and if infected, the age at which their symptoms developed was documented. Modifications were made over the course of this study with curtailment of enrollment on March 30, 1993. This five year study showed that HIV-1 infection can adversely impact pregnancy outcome and women's health, independent of substance abuse. On the other hand, substance use was the most important factor influencing immediate neonatal outcome. Data from this study provided part of the information base to justify the development of ACTG 076. The total number of evaluable cases was 164 and the number of evaluable infants was 146. Repository specimens are providing the resources to study patterns of viral resistance in perinatal transmission.

Descriptors :   *HUMAN IMMUNODEFICIENCY VIRUSES, *PREGNANCY, *WOMEN, *FETUS, *INFECTIOUS DISEASE TRANSMISSION, RISK, HEALTH, SIGNS AND SYMPTOMS, IMMUNOLOGY, INFECTIOUS DISEASES, BLOOD SERUM, VIRUS DISEASES, IMMUNOASSAY, SEROLOGY, ANTIGEN ANTIBODY REACTIONS, MORBIDITY, DRUG ABUSE, INFANTS, RETROVIRUSES, DRUG ADDICTION, OBSTETRICS.

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE