Accession Number : ADA314090

Title :   A Comprehensive Repository of Normal and Tumor Human Breast Tissue and Cells.

Descriptive Note : Annual rept. 1 Jul 95-30 Jun 96,

Corporate Author : TEXAS UNIV AT DALLAS

Personal Author(s) : Shay, Jerry W.

PDF Url : ADA314090

Report Date : JUL 1996

Pagination or Media Count : 9

Abstract : The development of breast cancer is likely to be a multi-step progressive process with several heritable alterations accumulated during the evolution to malignancy. In order to have surrogate endpoint markers to provide a means for early intervention, it is important to define the specific molecular alterations at each stage of this process. The study of such alterations should be greatly facilitated by having not only cells derived from breast tumors but also corresponding non-malignant breast cells of stromal and epithelial origin. We have successfully established a unique repository which contains cryopreserved and cultured cells from human breast tumor tissues, non-malignant breast epithelial and stromal cells and peripheral blood mononuclear cells.

Descriptors :   *CELLS(BIOLOGY), *MAMMARY GLANDS, *BLOOD CELLS, *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), HUMANS, NEOPLASMS, EVOLUTION(GENERAL), HUMAN BODY, INTERVENTION, NUCLEI.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE