Accession Number : ADA314173

Title :   Early Detection of Breast Cancer and Recurrence Following Therapy with Magnetic Resonance Imaging and Spectroscopy.

Descriptive Note : Annual rept. Mar 95-Apr 96,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : Solin, Lawrence ; Lenkinski, Robert E.

PDF Url : ADA314173

Report Date : APR 1996

Pagination or Media Count : 51

Abstract : We have successfully developed a technical approach that can be employed to produce MRS spectra of the breast lesions as small as (6 mm)3. These methods have been applied to a cohort of 35 patients. Using the presence of choline in the MR spectra as an indicator of malignancy, the positive predictive value is 0.90. This observation indicates that MRS may be employed in several ways. First it may provide a method for the improved distinction between benign and malignant lesions. Second the presence of choline may provide a means for differentiating recurrent tumor from radiation induced fibrosis. Finally, changes in the choline peak may provide a means for assessing response to therapy in patients with locally advanced breast cancer. Each of these three methods merits further investigation. Future directions that this project may take include: (1) MRS studies of breast lesions at 4.0 T, (2) determining the incremental diagnostic efficiency of MRS, and (3) carrying; out an analysis of the cost effectiveness of MRS as a diagnostic method.

Descriptors :   *DETECTION, *THERAPY, *NUCLEAR RADIATION SPECTROSCOPY, *BREAST CANCER, *MAGNETIC RESONANCE IMAGING, TISSUES(BIOLOGY), CHOLINES, NEOPLASMS, MORTALITY RATE, WOMEN, HISTOPATHOLOGY, LESIONS, MAMMARY GLANDS, BIOPSY, CYSTS, FIBROSIS, MAMMOGRAPHY.

Subject Categories : Medicine and Medical Research
      Atomic and Molecular Physics and Spectroscopy

Distribution Statement : APPROVED FOR PUBLIC RELEASE