Accession Number : ADA314521

Title :   The Genetic Analysis of the Role of Neu Differentiation Factor (Heregulin) in Neu-Induced Mammary Carcinomas in the Mouse.

Descriptive Note : Annual rept. 15 Jul 95-14 Jun 96,

Corporate Author : YALE UNIV NEW HAVEN CT

Personal Author(s) : Perkins, Archibald

PDF Url : ADA314521

Report Date : JUL 1996

Pagination or Media Count : 12

Abstract : We are investigating the need for cooperating genes in the development of ErbB2-induced mammary tumors using the mouse as a model system. In one set of experiments, we are investigating the role of ligands for the ErbB family of tyrosine kinase receptors, specifically focusing on NDF. Using a transgenic approach, we are investigating the effect of different NDF isoforms and mutant NDFs on ErbB2-induced tumors in the mouse. In a second set of experiments, hypomorphic alleles are being created at NDF, to determine the contribution of this gene in ErbB2-induced tumors. Finally, in a wider screen to identify genes that can cooperate in ErbB2-induced mammary carcinogenesis, we are performing MMTV-mutagenesis in ErbB2 transgenics to activate and tag cooperating oncogenes, with the goal of isolating and characterizing these genes.

Descriptors :   *GENETICS, *MAMMARY GLANDS, *ONCOGENIC VIRUSES, *BREAST CANCER, MODELS, LIGANDS, GENES, MICE, CANCER, MAMMOGRAPHY.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE