Accession Number : ADA314881

Title :   Studies on Human Breast Cancer and Transforming Growth Factor-beta Application for a Career Development Award.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : DARTMOUTH COLL HANOVER NH

Personal Author(s) : Arrick, Bradley A.

PDF Url : ADA314881

Report Date : OCT 1995

Pagination or Media Count : 9

Abstract : This is a career development award. The primary focus of the research is the expression and function of TGF-Beta by breast cancer cells. For established tumors, overexpression of TGF-B may result in increased in vivo tumor growth and metastatic spread. The first objective involves the analysis of resected breast cancer specimens, with the goal of confirming our prior work correlating clinical outcome with TGF-B expression levels in tumors. There are as yet no definitive data or conclusions from this aspect of the work. The second objective of the grant was to evaluate the impact of TGF-Beta on the tumorigenic and metastatic potential of human breast cancer cell lines in nude mice. We have made progress on generating the transfected cell clones, but do not yet have data regarding animal studies. The third research objective is the analysis of the regulation of TGF-Beta expression in breast cancer cells. We have made some progress in designing required promoter constructs for this work, but do not have data as yet.

Descriptors :   *HUMANS, *NEOPLASMS, *BREAST CANCER, TISSUES(BIOLOGY), QUANTITATIVE ANALYSIS, CLINICAL MEDICINE, DEOXYRIBONUCLEIC ACIDS, NODES, MOLECULAR BIOLOGY, GENES, CLONES, STATISTICAL ANALYSIS, IN VIVO ANALYSIS, CELLS(BIOLOGY), RIBONUCLEIC ACIDS, METASTASIS.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE