Accession Number : ADA315230

Title :   Electrically Mediated Trauma Repair.

Descriptive Note : Annual rept. 22 Aug 95-21 Aug 96,

Corporate Author : PURDUE RESEARCH FOUNDATION LAFAYETTE IN

Personal Author(s) : Borgens, Richard B.

PDF Url : ADA315230

Report Date : SEP 1996

Pagination or Media Count : 20

Abstract : In the second year of this contract period we have made substantial progress in experiments designed to facilitate recovery of functions following severe acute spinal cord injury in the adult mammal. The intervention is through the use of applied voltage gradients. We have shown that this technique can be used in conjunction with polymeric tubes to induce and guide regenerating axons. We have also developed novel two and three-dimensional reconstruction techniques and morphometry to assay our biological responses to treatment between control and experimental groups. Using these, we have assayed the level of macrophage infestation of acute and subacute spinal cord injuries.

Descriptors :   *WOUNDS AND INJURIES, *CENTRAL NERVOUS SYSTEM, *TRAUMA, *SPINAL CORD, MAMMALS, MORPHOLOGY, VOLTAGE, REPAIR, RESPONSE(BIOLOGY), AXONS, ASSAYING, ADULTS, GRADIENTS.

Subject Categories : Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE