Accession Number : ADA315470
Title : Mechanisms of the Basal Ganglia for Arm-Hand Coordination.
Descriptive Note : Final rept. 1 Jun 93-31 Aug 96,
Corporate Author : CALIFORNIA UNIV LOS ANGELES DEPT OF COMPUTER SCIENCE
Personal Author(s) : Arbib, Michael A.
PDF Url : ADA315470
Report Date : 30 SEP 1996
Pagination or Media Count : 66
Abstract : The basal ganglia (BG) appears to play a dual role in the performance of voluntary movements: (1) the direct path is primarily involved in providing an estimate of the next sensory state to the cortex, and (2) the indirect path is mainly responsible for the inhibition of movement while the cortex is either involved in choosing the next motor command for execution, or while waiting for a 'go' signal to indicate the end of a delay period. Its strong ties with the supplementary motor area (SMA), a region involved with planning sequential movements, suggest the basal ganglia assists in movement planning and performance by providing the SMA with information regarding the expected state, such that SMA may begin planning the next sequence of the behavior. Disruption of normal motor function, such as that seen in Parkinson's disease, demonstrates a difficulty in performing sequential movements, with some patients exhibiting slower movement or a pause between sequences. This may be attributed to the indirect pathway, which prevents the next sensory state from reaching the cortex, thus inhibiting it from preparing to execute the next movement in a sequence. A computer model of neural networks involved in arm movement was-developed to demonstrate the suggested relationship between the two pathways.
Descriptors : *PSYCHOMOTOR FUNCTION, *GANGLIA, COMPUTERIZED SIMULATION, FUNCTIONS, PERFORMANCE(HUMAN), BEHAVIOR, INHIBITION, SENSES(PHYSIOLOGY), HANDS, ARMS(ANATOMY), CEREBRAL CORTEX.
Subject Categories : Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE