Accession Number : ADA315695

Title :   Breast Cancer Incidence in Occupational Cohorts Exposed to Ethylene Oxide and Polychlorinated Biphenyls.

Descriptive Note : Annual rept. 1 Aug 95-31 Jul 96,

Corporate Author : NATIONAL INST FOR OCCUPATIONAL SAFETY AND HEALTH CINCINNATI OH

Personal Author(s) : Ward, Elizabeth M.

PDF Url : ADA315695

Report Date : AUG 1996

Pagination or Media Count : 11

Abstract : NIOSH is evaluating breast cancer incidence in two large study cohorts, which have been previously assembled. One of the cohorts includes approximately 10,000 women with exposure to ethylene oxide (ETO), a direct alkylating agent which produces mammary tumors in mice. The other cohort includes over 13,000 women exposed to polychlorinated biphenyls (PCBs), a group of chemicals suspected to be carcinogenic to the breast because of their lipophilic and estrogenic activities. Each cohort represents the largest and best defined female study cohort in the U.S. for the respective exposure. The primary activities for this year have focused on establishing vital status and mailing addresses for individuals in the two study cohorts, and seeking OMB approval for the study questionnaires. Work to accomplish vital status and address identification is proceeding in a timely fashion. OMB approval was received in April of 1996

Descriptors :   *POLYCHLORINATED BIPHENYLS, *ETHYLENE OXIDE, *BREAST CANCER, CHEMICALS, NEOPLASMS, ALKYLATION, EXPOSURE(PHYSIOLOGY), MICE, CARCINOGENS, QUESTIONNAIRES, FEMALES, MAMMARY GLANDS, BIPHENYL.

Subject Categories : Medicine and Medical Research
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE