Accession Number : ADA315811

Title :   Cell Cycle in Normal and Malignant Breast Epithelial Cells.

Descriptive Note : Annual rept. 1 Jul 95-30 Jun 96,

Corporate Author : SCRIPPS RESEARCH INST LA JOLLA CA

Personal Author(s) : Reed, Steven I.

PDF Url : ADA315811

Report Date : JUL 1996

Pagination or Media Count : 31

Abstract : Breast cancer is a disease where breast epithelial cells become refractory to appropriate growth and differentiation signals. It is likely that numerous genetic changes can contribute to malignant transformation, including mutations that alter the cell cycle regulatory machinery. We have therefore sought to characterize the function of both positive and negative cell cycle regulatory elements in normal and malignant breast epithelial cells. In particular, we have focused on cyclin E, a positive cell cycle regulators element already implicated in some breast malignancies and on a class of negative regulators of cyclin-dependent kinases (Cdks). Preliminary data indicate that both cyclin B and Cdk inhibitors are important in breast malignancy. malignancy.

Descriptors :   *EPITHELIUM, *CELLS(BIOLOGY), *MAMMARY GLANDS, *BREAST CANCER, CYCLES, MUTATIONS, REGULATORS, GENETICS, CANCER.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE