Accession Number : ADA315910

Title :   Program for Critical Technologies in Breast Oncology.

Descriptive Note : Annual rept. 1 Jul 95-30 Jun 96,

Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s) : Costa, Jose

PDF Url : ADA315910

Report Date : JUL 1996

Pagination or Media Count : 165

Abstract : The description of work accomplished is presented under five headings: (1) collection of samples; (2) establishment of a database; (3) preparation and distribution of samples; (4) development of assays relevant to breast cancer; and (5) supplemental activities. (1) We have established protocols for collection and utilization of tissues at Yale and at fourteen off-site hospitals. We also have initiated or obtained IRB approval in all sites, and have trained/are training technical personnel. (2) We are implementing the database proposed in the original application. In addition, we have initiated a data exchange program with the Yale Cancer Center, Yale-New Haven Hospital, and the Yale Tumor Registry. (3) We have collected in the past year a total of 3754 samples of breast tissues from 1016 cases. We have distributed 8335 tissue-derived products to investigators. (4) We have developed assays to assess the status of pS3, Ki-ras, cyclin D-l (PRAD), neu/erbB-2, microsatellite variability, pl6 (MTS), AP-2, human Disheveled (hDsh), phospho-neu/erbB-2 (p185), and others. (5) We participate in a working group addressing the ethical and legal issues raised by storing samples linked to medical information concerning individual patients.

Descriptors :   *NEOPLASMS, *MAMMARY GLANDS, *BREAST CANCER, DATA BASES, TISSUES(BIOLOGY), INFORMATION EXCHANGE, DISTRIBUTION, TECHNICIANS, MEDICINE, SAMPLING, LINKAGES, UTILIZATION, ASSAYING, CANCER, ADDRESSING.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE